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Rimonabant is not yet approved for use in the United States, where it is known as Zimulti. 16 issue of the British Medical Journal, Padwal's team found that long-term users of weight-loss drugs such as orlistat (Xenical), sibutramine (Meridia) and rimonabant experienced only modest weight loss -- less than 11 pounds, which was less than 5 percent of their total body weight. "If one is using rimonabant, patients should be monitored carefully for the emergence of depressive symptoms and/or suicidal thoughts," he added. Effects Of The Cannabinoid-1 Receptor Blocker Rimonabant On Weight Reduction And Cardiovascular Risk Factors In Overweight Patients: 1-Year Experience From The RIO-Europe Study. A CB1 antagonist called rimonabant is currently marketed overseas for weight loss. Effect of Rimonabant on Body Weight and the Metabolic Syndrome in Overweight Patients.

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